Реакция #2467952

Уравнение реакции

L-Ala-L-Phe

pyridine

acetic anhydride

water

→

N-[2-(acetylamino)propionyl]phenylalanine

Растворители

methylene chloride

Условия реакции

Обработка

1. 1
   Экстракцияthe resulting mixture is extracted three times with chloroform
2. 2
   ПромывкаThe organic layer is washed with a saturated aqueous solution of sodium chloride
3. 3
   Сушкаdried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONthe solvent is distilled away under reduced pressure

Методика

L-Ala-L-Phe obtained in Experimental Example 6 (100 mg, 0.423 mmol) is suspended in methylene chloride (10 ml), and pyridine (10 ml) and acetic anhydride (1 ml, 11 mmol) are added to the suspension at room temperature. After stirring at room temperature for 24 hours, water is added and the resulting mixture is extracted three times with chloroform. The organic layer is washed with a saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate, and then the solvent is distilled away under reduced pressure to obtain N-[2-(acetylamino)propionyl]phenylalanine.

Источник