Реакция #2467018

Уравнение реакции

2-acetylaminomethyl-5-bromoacetylthiazole

diaminomethylenethiourea

→

4-(2-acetylaminomethylthiazol-5-yl)-2-(diaminomethyleneamino)thiazole dihydrobromide

Выход 42.4%

Растворители

acetone

Условия реакции

Обработка

1. 1
   Температураwas refluxed for 10 hours
2. 2
   ФильтрацияThe resulting precipitate was collected by filtration

Методика

A mixture of 2-acetylaminomethyl-5-bromoacetylthiazole (6.30 g) and diaminomethylenethiourea [(H2N)2C=NCSNH2 ] (1.77 g) in acetone (90 ml) was refluxed for 10 hours with stirring. The resulting precipitate was collected by filtration to give 4-(2-acetylaminomethylthiazol-5-yl)-2-(diaminomethyleneamino)thiazole dihydrobromide (2.21 g).

Источник