Реакция #2467014

Уравнение реакции

2-(acetylaminometyl)-6-bromoacetylpyridine hydrobromide

diaminomethylenethiourea

→

4-(6-aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole

Выход 42.4%

Растворители

methanol

Условия реакции

Обработка

1. 1
   Температураwas refluxed for 10 hours
2. 2
   ДругоеThe resulting precipitate was collected
3. 3
   workup.DISSOLUTIONdissolved in water (50 ml)
4. 4
   ДругоеThe separated product was collected
5. 5
   Промывкаwashed with water

Методика

A mixture of 2-(acetylaminometyl)-6-bromoacetylpyridine hydrobromide (3.34 g) and diaminomethylenethiourea (1.01 g) in methanol (50 ml) was refluxed for 10 hours with stirring. The resulting precipitate was collected, dissolved in water (50 ml) and the solution was made basic with aqueous potassium carbonate. The separated product was collected and washed with water to give 4-(6-aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole (0.90 g).

Источник