Реакция #2457000

Уравнение реакции

tert-butyl [(1S)-2-azido-1-phenylethyl]carbamate

dioxane

→

(S)-2-Azido-1-phenyl-ethylamine

Выход 85.0%

Растворители

THF

hydrogen chloride

ether

Условия реакции

Обработка

1. 1
   ФильтрацияThe precipitate was filtered
2. 2
   Промывкаwashed with ether

Методика

To a solution of tert-butyl [(1S)-2-azido-1-phenylethyl]carbamate (210 mg, 0.8 mmol, 1.0 eq.) in THF (2 ml), 4.0M hydrogen chloride in dioxane (2.0 ml, 8.0 mmol, 10.0 eq.) was added. The reaction mixture was stirred at room temperature overnight. The reaction mixture was diluted with ether. The precipitate was filtered and washed with ether to yield (S)-2-Azido-1-phenyl-ethylamine 40 as a white solid in 85% yield. LC-MS [163 (M+1)]

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