Реакция #2446080

Уравнение реакции

tert-butyl cyclohexyl(2-hydroxypropyl)carbamate

2,4,6-trimethyl-benzoyl chloride

→

1-((tert-butoxycarbonyl)(cyclohexyl)amino)propan-2-yl 2,4,6-trimethylbenzoate

Растворители

ethyl acetate

toluene

Условия реакции

Обработка

1. 1
   ДругоеThe resultant reaction mixture
2. 2
   Промывкаwashed with water and brine
3. 3
   СушкаThe organic layer was dried over sodium sulphate
4. 4
   Концентрированиеconcentrated to dryness

Методика

To a solution of tert-butyl cyclohexyl(2-hydroxypropyl)carbamate (1 g, 3.89 mmol) in dry toluene (10 ml), 2,4,6-trimethyl-benzoyl chloride (0.510 mL, 4.280 mmol) was added. The resultant reaction mixture was stirred at rt for 16 hours. The reaction mixture was diluted in ethyl acetate and washed with water and brine. The organic layer was dried over sodium sulphate, and concentrated to dryness to obtain 1-((tert-butoxycarbonyl)(cyclohexyl)amino)propan-2-yl 2,4,6-trimethylbenzoate. Yield: 1 g (64.10%); LCMS: m/z=404.4 [M+H], RT=2.76 min, (Column: Y, Program: P1)

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