Реакция #2439941

Уравнение реакции

2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [3-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-5-carbonyl)-phenyl]-amide

3-aminophenol

→

title compound

Выход 79.2%

2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid (3-{3-[(3-hydroxy-phenylamino)-methylene]-2-oxo-2,3-dihydro-1H-indole-5-carbonyl}-phenyl)-amide

Выход 79.2%

Растворители

THF

—

Hexanes

Условия реакции

Обработка

1. 1
   ДругоеA small screw cap test tube
2. 2
   ТемператураSubsequently, the reaction mixture was cooled to room temperature
3. 3
   ДругоеThe solid precipitate that formed

Методика

A small screw cap test tube was charged with 2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [3-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-5-carbonyl)-phenyl]-amide (as prepared in Example 1, 30 mg, 0.072 mmol) and THF (1 mL). To the resulting solution was added 3-aminophenol (11.8 mg, 0.1082 mmol), and the mixture was stirred for 24 h at 65° C. Subsequently, the reaction mixture was cooled to room temperature. Hexanes were added to the reaction mixture. The solid precipitate that formed was washed with ˜1 mL of i-prOH yielding 79% (29 mg, 0.057 mmol) of the title compound.

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