Реакция #2439938

Уравнение реакции

2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid

thionyl chloride

5-(3-Amino-benzoyl)-1,3-dihydro-indol-2-one

→

2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-5-carbonyl)-phenyl]-amide

Выход 76.0%

Растворители

THF

Условия реакции

Обработка

1. 1
   ДругоеThe thionyl chloride was then removed by distillation
2. 2
   ТемператураThe crude acid chloride was cooled to room temperature
3. 3
   workup.DISSOLUTIONdissolved in THF (5 mL)
4. 4
   Температураto reflux for 2 h
5. 5
   Температураto cool to room temperature
6. 6
   ДругоеThe room temperature reaction mixture
7. 7
   Концентрированиеwas concentrated in vacuo
8. 8
   workup.DISSOLUTIONthe crude residue was dissolved in EtOH (5 mL)
9. 9
   workup.ADDITIONThe ethanolic solution was treated with 1M NaOH(aq) (2 mL)
10. 10
    workup.STIRRINGstirred for 30 min
11. 11
    Другоеyielding a tan precipitate
12. 12
    ФильтрацияThe tan solids were filtered

Методика

A dry 25 mL flask was charged with 2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid (0.802 g, 4.67 mmol) and thionyl chloride (10 mL) and allowed to stir at 79° C. for 2 h. The thionyl chloride was then removed by distillation. The crude acid chloride was cooled to room temperature, and then dissolved in THF (5 mL). 5-(3-Amino-benzoyl)-1,3-dihydro-indol-2-one (0.905 g, 3.59 mmol) was added to the THF solution of the acid chloride, and the mixture was allowed to reflux for 2 h. The reaction mixture was then allowed to cool to room temperature. The room temperature reaction mixture was concentrated in vacuo, and the crude residue was dissolved in EtOH (5 mL). The ethanolic solution was treated with 1M NaOH(aq) (2 mL) and stirred for 30 min. The basic solution was acidified to a pH of 1 with 1M HCl(aq) yielding a tan precipitate. The tan solids were filtered to afford the pure 2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-5-carbonyl)-phenyl]-amide (1.05 g, 2.73 mmol, 76%).

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