Реакция #2420

ord-b9cf0611d38749c6a169a2037a147be6

Уравнение реакции

O=C1N[C@H](c2ccccc2)CO1
(R)-4-phenyl-2-oxazolidinone
[H-].[Na+]
NaH
C1CCOC1
THF
CCCC[N+](CCCC)(CCCC)CCCC.O=C1N[C@H](c2ccccc2)CO1
(R)-4-phenyl-2-oxazolidinone tetra n-butylammonium salt

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

To a stirred solution of (R)-4-phenyl-2-oxazolidinone (174 mg, 1.06 mmol) in THF (4 mL) at 0° C., add NaH (4.3 mg, 60% emulsion in oil, 0.106 mmol). Allow the temperature to rise to room temperature over 30 min., then add tetra n-butylammonium bromide (34 mg, 0.106 mmol) to the mixture and stir for another 30 min. to obtain (R)-4-phenyl-2-oxazolidinone tetra n-butylammonium salt.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US05728827uspto-grants-1998_03