Реакция #2410

Уравнение реакции

2-(6-aminopyrimidin-4-yloxy)ethanol

bromine

→

2-(6-amino-5-bromopyrimidin-4-yloxy)ethanol

Выход 104.7%

Растворители

methanol

methanol

Условия реакции

Обработка

1. 1
   ДругоеThe mixture is evaporated
2. 2
   Другоеto remove the solvent
3. 3
   workup.DISSOLUTIONthe residue is dissolved in ethyl acetate
4. 4
   workup.ADDITIONThe mixture is treated with saturated aqueous sodium hydrogen carbonate solution
5. 5
   Экстракцияextracted with ethyl acetate/tetrahydrofuran
6. 6
   ПромывкаThe organic layer is washed
7. 7
   Другоеdried
8. 8
   Другоеevaporated
9. 9
   Другоеto remove the solvent

Методика

To a suspension of 2-(6-aminopyrimidin-4-yloxy)ethanol (400 mg) in methanol (4 ml) is added dropwise a solution of bromine (437 mg) in methanol (2 ml). The mixture is evaporated to remove the solvent, and the residue is dissolved in ethyl acetate. The mixture is treated with saturated aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate/tetrahydrofuran. The organic layer is washed, dried, and evaporated to remove the solvent to give 2-(6-amino-5-bromopyrimidin-4-yloxy)ethanol (632 mg).

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