Реакция #2408

Уравнение реакции

water

2-(6-chloropyrimidin-4-yloxy)ethanol

sodium azide

→

2-(6-azidopyrimidin-4-yloxy)ethanol

Выход 28.9%

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling
2. 2
   Экстракцияextracted with ethyl acetate
3. 3
   СушкаThe ethyl acetate layer is dried
4. 4
   Другоеevaporated
5. 5
   Другоеto remove the solvent
6. 6
   ДругоеThe residue is purified by silica gel column chromatography (solvent; hexane/ethyl acetate=1:1)

Методика

To a solution of 2-(6-chloropyrimidin-4-yloxy)ethanol (5.61 g) in dimethylformamide (60 ml) is added sodium azide (4.18 g), and the mixture is stirred at 70° C. for 20 hours. After cooling, the reaction solution is treated with water, and extracted with ethyl acetate. The ethyl acetate layer is dried, and evaporated to remove the solvent. The residue is purified by silica gel column chromatography (solvent; hexane/ethyl acetate=1:1) to give 2-(6-azidopyrimidin-4-yloxy)ethanol (1.68 g).

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