Реакция #2407

Уравнение реакции

4,6-dichloropyrimidine

ethylene glycol

sodium hydride

→

2-(6-chloropyrimidin-4-yloxy)ethanol

Растворители

tetrahydrofuran

Условия реакции

Обработка

1. 1
   Температураcooling
2. 2
   Другоеevaporated
3. 3
   Другоеto remove the solvent
4. 4
   ЭкстракцияThe residue is extracted with ethyl acetate
5. 5
   Экстракцияthe ethyl acetate extract
6. 6
   Другоеis dried
7. 7
   Концентрированиеconcentrated under reduced pressure
8. 8
   ДругоеThe residue is purified by silica gel column chromatography (solvent; chloroform/ethyl acetate=5:1~2:1)

Методика

To a mixture of 4,6-dichloropyrimidine (5.0 g), ethylene glycol (100 ml) and tetrahydrofuran (100 ml)is added sodium hydride (60% dispersion-type, 1.34 g) under ice-cooling. The mixture is stirred at the same temperature for two hours, and evaporated to remove the solvent. The residue is extracted with ethyl acetate, and the ethyl acetate extract is dried, and concentrated under reduced pressure. The residue is purified by silica gel column chromatography (solvent; chloroform/ethyl acetate=5:1~2:1) to give 2-(6-chloropyrimidin-4-yloxy)ethanol (5.67 g) as an oily product.

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