Реакция #2398

Уравнение реакции

2-{6-chloro-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol

sodium azide

dimethyformamide

→

2-{6-azido-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol

Выход 87.5%

Растворители

water

Условия реакции

Обработка

1. 1
   Температураis heated
2. 2
   ТемператураAfter cooling
3. 3
   Экстракцияextracted with ethyl acetate
4. 4
   ПромывкаThe ethyl acetate layer is washed
5. 5
   Другоеdried
6. 6
   Другоеevaporated
7. 7
   Другоеto remove the solvent
8. 8
   ДругоеThe residue is crystallized from hexane

Методика

A mixture of 2-{6-chloro-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol (21.85 g), sodium azide (10.7 g) and dimethyformamide (260 ml) is heated with stirring at 75°-80° C. overnight. After cooling, the mixture is treated with water, and extracted with ethyl acetate. The ethyl acetate layer is washed, dried, and evaporated to remove the solvent. The residue is crystallized from hexane to give 2-{6-azido-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol (19.6 g).

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