Реакция #2389080

Уравнение реакции

4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one

hydrogen

sodium acetate

→

nabumetone

Растворители

water

isopropanol

isopropanol

Условия реакции

Обработка

1. 1
   ПромывкаThe hydrogenator is washed with nitrogen in order
2. 2
   workup.ADDITIONhydrogen is introduced at the pressure of 2.5 atmospheres
3. 3
   ДругоеFor a period of time of 9 hours the temperature of reaction
4. 4
   Другоеis kept at 50° C.
5. 5
   Промывкаthe hydrogenator is washed with nitrogen
6. 6
   Фильтрацияthe reaction mixture is filtered in order
7. 7
   КонцентрированиеThe solution is concentrated to 130 ml
8. 8
   workup.ADDITIONdiluted with 45 ml of water
9. 9
   workup.ADDITIONadded with 18.2 g of sodium metabisulfite
10. 10
    Температураis cooled to 0° C
11. 11
    ДругоеThe so obtained suspension
12. 12
    workup.WAITis kept at 0° C. for two hours
13. 13
    Фильтрацияis filtered
14. 14
    Промывкаthe solid is washed with 60 ml of isopropanol
15. 15
    Температураcooled to 0° C.
16. 16
    Температураhalf at room temperature, then is heated at 60° C.
17. 17
    Другоеthe layers are separated
18. 18
    ПромывкаThe organic phase is washed with 60 ml of water
19. 19
    Концентрированиеis concentrated under vacuum at 60° C. until an oil
20. 20
    Другоеis obtained which
21. 21
    Температураby cooling
22. 22
    Температураthe resulting solution is cooled to 0° C. in two hours
23. 23
    workup.WAITThe obtained suspension is kept for one hour at this temperature
24. 24
    Фильтрацияfiltered
25. 25
    Промывкаwashed with 10 ml of cold isopropanol
26. 26
    Другоеdried in oven under vacuum until constant weight

Методика

49.44 Grams (0.154 moles) of 4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one, 12.24 g (0.149 moles) of anhydrous sodium acetate, 4 g of a 50% suspension in water of 5% palladium on carbon, equivalent to 0.00094 moles of palladium and 400 ml of isopropanol are put into a hydrogenator. The hydrogenator is washed with nitrogen in order to eliminate the oxygen and then hydrogen is introduced at the pressure of 2.5 atmospheres. For a period of time of 9 hours the temperature of reaction is kept at 50° C., then the hydrogen is let off, the hydrogenator is washed with nitrogen and the reaction mixture is filtered in order to eliminate the catalyst. The solution is concentrated to 130 ml, diluted with 45 ml of water, heated to 60° C. and added with 18.2 g of sodium metabisulfite. The reaction mixture is kept for one hour at 60° C. and then is cooled to 0° C. The so obtained suspension is kept at 0° C. for two hours and then is filtered; the solid is washed with 60 ml of isopropanol cooled to 0° C. and then is suspended in a mixture made by 70 ml of a 10% aqueous solution of sodium hydroxide and 270 ml of toluene. The reaction mixture is stirred for one hour and half at room temperature, then is heated at 60° C. and the layers are separated. The organic phase is washed with 60 ml of water and is concentrated under vacuum at 60° C. until an oil is obtained which solidifies by cooling. The solid is dissolved at 60° C. in 40 ml of isopropanol and the resulting solution is cooled to 0° C. in two hours. The obtained suspension is kept for one hour at this temperature, filtered, washed with 10 ml of cold isopropanol and dried in oven under vacuum until constant weight. 26.3 Grams of nabumetone are obtained with a yield equal to 74.8%.

Источник