Реакция #2383793

Уравнение реакции

2,3,4,5-tetrahydro-1,4-benzoxazepin-5-one

potassium nitrate

→

title compound

Выход 22.2%

7-Nitro-2,3,4,5-tetrahydro-1,4-benzoxazepin-5-one

Выход 22.2%

Растворители

sulfuric acid

Условия реакции

Обработка

1. 1
   workup.WAITfor 4 h at room temperature
2. 2
   Фильтрацияthe solids were collected by filtration
3. 3
   Температураcooled

Методика

To 2,3,4,5-tetrahydro-1,4-benzoxazepin-5-one (30.34 g, 190 mmol) in conc. sulfuric acid (600 ml) at 0° C. was added potassium nitrate (20.82 g, 206 mmol) portionwise. The mixture was stirred for 20 minutes at 0° C. and then for 4 h at room temperature. The mixture was poured onto ice (21) and the solids were collected by filtration. The solids were taken up in hot ethyl acetate and then cooled to yield the title compound (8.79 g, 22%), MS m/z 209 [M+H]+.

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