Реакция #2358532

ord-52a5d864de2e474faa4622aef67e5f88

Уравнение реакции

CC(CO)NC(=O)c1cccc(C#CCCCC(=O)O)c1
6-[3-(2-Hydroxy-1-methyl-ethylcarbamoyl)phenyl]-hex-5-ynoic acid
CNC.Cl
dimethylamine hydrochloride
CC(CO)NC(=O)c1cccc(C#CCCCC(=O)N(C)C)c1
3-(5-Dimethylcarbamoyl-pent-1-ynyl)-N-(2-hydroxy-1-methyl-ethyl)benzamide
Выход 96.0%

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    Другоеto obtain 8 (0.115 g, 0.363 mmol; 96% yield)

Методика

6-[3-(2-Hydroxy-1-methyl-ethylcarbamoyl)phenyl]-hex-5-ynoic acid (4) (0.109 g, 0.377 mmol) was reacted using method C with dimethylamine hydrochloride to obtain 8 (0.115 g, 0.363 mmol; 96% yield).

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US09120723B2uspto-grants-2015_09