Реакция #2358531

ord-ff2d202e236b411f81ce809ef4869625

Уравнение реакции

CC(CO)NC(=O)c1cccc(I)c1
iodobenzamide
CC(CO)NC(=O)c1cccc(I)c1
N-(2-hydroxy-1-methyl-ethyl)-3-iodobenzamide
C#CCCCC(=O)O
5-hexynoic acid
CC(CO)NC(=O)c1cccc(C#CCCCC(=O)O)c1
( 4 )
Выход 99.0%
CC(CO)NC(=O)c1cccc(C#CCCCC(=O)O)c1
6-[3-(2-Hydroxy-1-methyl-ethylcarbamoyl)phenyl]-hex-5-ynoic acid
Выход 99.0%

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

The iodobenzamide (1) (2.00 g, 6.5 mmol) was coupled with 5-hexynoic acid using method B yielding (4) (1.87 g, 6.42 mmol; 99% yield).

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US09120723B2uspto-grants-2015_09