Реакция #2358525

Уравнение реакции

tert-butyl 2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl-carbamate

HCl

NaOH

→

title compound

Выход 78.6%

2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethanamine

Выход 78.6%

Растворители

EtOH

Условия реакции

Обработка

1. 1
   Экстракцияextracted with ethyl acetate (2×100 ml)
2. 2
   ПромывкаThe combined organic phase was washed with brine (75 ml)
3. 3
   Сушкаdried (Na2SO4)
4. 4
   Другоеevaporated

Методика

A mixture of tert-butyl 2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl-carbamate (1.4 g, 4.2 mmol) in EtOH (18 ml) was added HCl (1.25 M in EtOH, 6 ml). The mixture was stirred at ambient temperature for 20 h. The aqueous phase was made basic by addition of aqueous NaOH (1 M, 50 ml) and extracted with ethyl acetate (2×100 ml). The combined organic phase was washed with brine (75 ml), dried (Na2SO4) and evaporated to yield the title compound (0.77 g, 77%). MS m/z (relative intensity, 70 eV 298 (M+, 18), 296 (M+, 18), 109 (bp), 107 (99), 82 (15).

Источник