Реакция #2358486

Уравнение реакции

2-fluoro-4-(trifluoromethyl)benzaldehyde

methyl thioglycolate

potassium carbonate

DMF

→

methyl-6-(trifluoromethyl)benzo[b]thiophene-2-carboxylate

Выход 56.4%

Растворители

water

Условия реакции

Обработка

1. 1
   Температураthe reaction mixture was cooled to room temperature
2. 2
   Экстракцияextracted with tert-butyl methyl ether 3 times
3. 3
   ПромывкаThe combined organic layer was washed with water
4. 4
   СушкаThe mixture was dried over magnesium sulfate
5. 5
   Концентрированиеconcentrated under reduced pressure

Методика

A mixture of 1.11 g of 2-fluoro-4-(trifluoromethyl)benzaldehyde, 739 mg of methyl thioglycolate, 1.3 g of potassium carbonate and 20 ml of DMF was stirred at 140° C. for 2 hours, and then the reaction mixture was cooled to room temperature. To the reaction mixture was added water, and then extracted with tert-butyl methyl ether 3 times. The combined organic layer was washed with water, followed by saturated aqueous sodium chloride solution. The mixture was dried over magnesium sulfate, and then concentrated under reduced pressure to obtain 848 mg of methyl-6-(trifluoromethyl)benzo[b]thiophene-2-carboxylate (the present compound 2).

Источник