Реакция #2348095

Уравнение реакции

hydrogen

compound 1-3-3-9

1-(2,3-difluoro-4-ethoxy-6-methylphenyl)-2-(4-(4-propylcyclohexyl)cyclohexyl)ethene

→

1-(2,3-difluoro-4-ethoxy-6-methylphenyl)-2-(4-(4-propylcyclohexyl)cyclohexyl)ethane

Выход 80.7%

Растворители

toluene

Условия реакции

Обработка

1. 1
   Другоеwas not absorbed
2. 2
   ДругоеPd/C was removed
3. 3
   workup.DISTILLATIONthe solvent was distilled off
4. 4
   ДругоеThe residue was purified by silica gel column chromatography and recrystallization

Методика

0.31 g of Pd/C was added to 6.20 g of the compound 1-3-3-9 having been dissolved in 50 mL of toluene and 50 mL of Solmix, and under a hydrogen atmosphere, the mixture was stirred at room temperature until hydrogen was not absorbed. Pd/C was removed, and the solvent was distilled off. The residue was purified by silica gel column chromatography and recrystallization to obtain 5.03 g of 1-(2,3-difluoro-4-ethoxy-6-methylphenyl)-2-(4-(4-propylcyclohexyl)cyclohexyl)ethane (Compound 1-3-3-1) as colorless crystals.

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