Реакция #2345

Уравнение реакции

compound

Methyl 2-t-butoxycarbonylamino-4-[4-[4-(4-pyridyl)-piperazin-1-yl]phenoxy]butyrat

→

title compound

Выход 74.1%

Methyl 2-amino-4-[4-[4-(4-pyridyl) piperazin-1-yl]-phenoxy]butyrate

Выход 74.1%

Растворители

TFA

Условия реакции

Обработка

1. 1
   ДругоеThe solution was evaporated
2. 2
   workup.DISSOLUTIONthe residue dissolved in water (15 ml)
3. 3
   ЭкстракцияThe mixture was extracted three times with dichloromethane
4. 4
   ДругоеEvaporation of the combined extracts

Методика

The compound of Example 140 (0.96 g) in TFA (10 ml) was kept at room temperature for 2 hours. The solution was evaporated and the residue dissolved in water (15 ml) and the solution basified with sodium carbonate. The mixture was extracted three times with dichloromethane. Evaporation of the combined extracts gave the title compound (0.56 g); m.p. 125°-127° C.; NMR(d6DMSO) δ 8.2(2H,d), 6.92(6H,m), 4.0(2H,m), 3.64(3H,s), 3.46(4H,t), 3.15(4H,t), 2.04(2H,m), 1.84(1H, m); m/e 371(M+H)+. Calculated for C20H26N4 O3. 0.75 H2O: C, 62.5; H, 7.17; N, 14.6. Found: C, 62.8; H, 6.8; N, 14.3%.

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