Реакция #2336533

Уравнение реакции

2-Methylthiophenol

potassium carbonate

DMF

→

title compound

Выход 42.0%

3,6-Bis(2′-methylphenylthio) phthalonitrile

Выход 42.0%

Условия реакции

Обработка

1. 1
   ДругоеThe mixture was isolated
2. 2
   Другоеto give a yellow oil
3. 3
   ДругоеThe material was purified by flash column chromatography (eluting 10% ethyl acetate:isohexane)

Методика

2-Methylthiophenol (10.60 g, 85.5 mmol), potassium carbonate (11.82 g, 82.0 mmol) and ditosylated dicyanohydroquinone (20.00 g, 42.7 mmol) in DMF (75 mL) were reacted as described above. The mixture was isolated as described above to give a yellow oil. The material was purified by flash column chromatography (eluting 10% ethyl acetate:isohexane) to give the title compound as a yellow solid (8.85 g, 23.8 mmol, 42%). [Found: C, 70.7%; H, 4.6%; N, 7.5%; S, 17.2%; C22H16N2S2 requires C, 70.9%; H, 4.3%; N, 7.5%; S, 17.2%]; MS (EI+) 372 (M+, 100%), 357 (M-CH3, 8), 339 (20).

Источник