Реакция #2336518

Уравнение реакции

Ethyl 4-hydroxypyrimidine-5-carboxylate

LiOH.H2O

→

title compound 19

4-HYDROXYPYRIMIDINE-5-CARBOXYLIC ACID

Растворители

THF

MeOH

Условия реакции

Обработка

1. 1
   ДругоеThe mixture was quenched with conc. HCl (1 mL)
2. 2
   Экстракцияextracted with EtOAc (2×20 mL)
3. 3
   ЭкстракцияThe combined organic extract
4. 4
   Сушкаwas dried (MgSO4)
5. 5
   Концентрированиеconcentrated

Методика

Ethyl 4-hydroxypyrimidine-5-carboxylate can be prepared following the procedure of M. Pesson et al., Eur. J. Med. Chem.—Chim. Ther. 1974, 9, 585. A solution of this ester (500 mg, 3 mmol) in THF (10 mL) and MeOH (5 mL) was treated with LiOH.H2O (373 mg, 8.9 mmol) and stirred overnight. The mixture was quenched with conc. HCl (1 mL) and extracted with EtOAc (2×20 mL). The combined organic extract was dried (MgSO4) and concentrated to give 260 mg of the title compound 19 as an orange solid, m.p. 220° C. (dec). 4-HYDROXY-2-METHYLPYRIMIDINE-5-CARBOXYLIC ACID (20).

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