Реакция #2331745

Уравнение реакции

3-Amino-4-isobutyl amino quinoline

→

title compound

Выход 196.2%

1-Isobutyl-1H-imidazo-[4,5-c]-quinoline

Выход 196.2%

Растворители

formic acid

formic acid

Условия реакции

Обработка

1. 1
   ТемператураReflux
2. 2
   Температураwas maintained for 8-10 hrs
3. 3
   Другоеwas removed under reduced pressure and 3.5 L of water
4. 4
   workup.ADDITIONwas added to the concentrated mass
5. 5
   Другоеat 20° C
6. 6
   ТемператураThe reaction mass was further cooled to 10° C.
7. 7
   Другоеto obtain solid
8. 8
   ФильтрацияThe solid was filtered
9. 9
   Промывкаwashed with water
10. 10
    Другоеdried

Методика

3-Amino-4-isobutyl amino quinoline (215 gm, 1.0 mole) was dissolved in formic acid (1000 ml) and further refluxed the reaction mass to 110-115° C. Reflux was maintained for 8-10 hrs. After completion of reaction excess formic acid was removed under reduced pressure and 3.5 L of water was added to the concentrated mass. This diluted mass was then basified with 30% NaOH to pH (10 to 11) at 20° C. The reaction mass was further cooled to 10° C. and stirred for further 3 hrs to obtain solid. The solid was filtered, washed with water and dried to get the title compound (221 gm, 98%) as a white solid.

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