Реакция #2329

Уравнение реакции

Bromine

product

methyl 4-(2,2-dimethylacetyl)-phenoxyacetate

→

methyl 4-(2-bromo-2,2-dimethylacetyl)phenoxyacetate

Растворители

carbon tetrachloride

Условия реакции

Обработка

1. 1
   Другоеthe solvent was evaporated in vacuo
2. 2
   Другоеto give an orange oil
3. 3
   ФильтрацияA solution of this oil, in a small volume of dichloromethane, was filtered through silica
4. 4
   Другоеthe clear filtrate, on evaporation

Методика

Bromine (2.09 ml) was added dropwise over ten minutes to a stirred solution of the product of step (i) above (9.44 g) in carbon tetrachloride (200 ml). The solution was stirred for 16 hours, then the solvent was evaporated in vacuo to give an orange oil. A solution of this oil, in a small volume of dichloromethane, was filtered through silica and the clear filtrate, on evaporation, gave methyl 4-(2-bromo-2,2-dimethylacetyl)phenoxyacetate, 11.3 g, as a white crystalline solid: m.p. 46°-50° C.; NMR (d6DMSO) δ 8.09 (2H, d), 7.05 (2H, d), 4.92 (2H, s), 3.72 (3H, s), 2.0(6H, s).

Источник