Реакция #2328975

Уравнение реакции

trans-4-vinyl cyclohexane carboxylic acid

trimethylsilyl chloride

→

methyl trans-4-vinylcyclohexanecarboxylate

Растворители

methanol

Условия реакции

Обработка

1. 1
   Температураby refluxing for 6 hours
2. 2
   Концентрированиеconcentrated under reduced pressure
3. 3
   workup.ADDITION150 mL of hexane was added
4. 4
   Другоеthe methanol layer was separated
5. 5
   Экстракцияthe methanol layer was extracted with hexane
6. 6
   Промывкаthe mixture was washed with saturated saline
7. 7
   СушкаThe organic layer was dried over anhydrous sodium sulfate
8. 8
   Концентрированиеconcentrated

Методика

All of trans-4-vinyl cyclohexane carboxylic acid was dissolved in 120 mL of methanol and 0.1 g of trimethylsilyl chloride was added, followed by refluxing for 6 hours. The solution was cooling to room temperature and then concentrated under reduced pressure. 150 mL of hexane was added and the methanol layer was separated, and then the methanol layer was extracted with hexane. After combining with the organic layer, the mixture was washed with saturated saline. The organic layer was dried over anhydrous sodium sulfate and then concentrated to obtain 29.5 g of methyl trans-4-vinylcyclohexanecarboxylate.

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