Реакция #2325

Уравнение реакции

Charcoal

product

4-acetylamino-1-benzylpiperidine

hydrochloric acid

hydrogen

→

4-acetylaminopiperidine hydrochloride

Растворители

methanol

Условия реакции

Обработка

1. 1
   Другоеhydrogenated at room temperature
2. 2
   Фильтрацияthen filtered through diatomaceous earth
3. 3
   Другоеthe filtrate evaporated to dryness

Методика

10% w/w Palladium on charcoal (1.5 g) was added to a solution of the product from step (i) (10.0 g), 1 molar hydrochloric acid (21.5 ml) and methanol (150 ml) and the mixture hydrogenated at room temperature and pressure until the theoretical amount of hydrogen had been taken up. Charcoal was added, the mixture stirred for 1 hour then filtered through diatomaceous earth and the filtrate evaporated to dryness giving 4-acetylaminopiperidine hydrochloride, 8.64 g, as a sticky foam: NMR (CDCl3 +d6DMSO). δ 9,72(1H,b), 9.02(1H,b), 7.40(1H,bd), 3.87(1H,m), 3.30(2H,m), 2.81(2H,m), 1.86(4H,m), 1.80(3H,s); m/e 143 (M+H)+.

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