Реакция #2320128

Уравнение реакции

magnesium dioxide

1-phenyl-4-methyl-3,4-dihydroisoquinoline

→

pure yellow crystals

Выход 42.5%

1-phenyl-4-methylisoquinoline

Выход 42.5%

Растворители

benzene

Условия реакции

Обработка

1. 1
   ТемператураThe reaction mixture was heated
2. 2
   Температураat reflux for 16 hours
3. 3
   ДругоеThe magnesium dioxide was removed by vacuum filtration
4. 4
   Промывкаwashed with methylene chloride
5. 5
   ДругоеEvaporation of the solvent

Методика

To a suspension of activated magnesium dioxide (270 g, 0.132 mol) in 550 mL of benzene was added 1-phenyl-4-methyl-3,4-dihydroisoquinoline (29.0 g, 0.131 mol) with stirring. The reaction mixture was heated at reflux for 16 hours. The magnesium dioxide was removed by vacuum filtration and washed with methylene chloride. Evaporation of the solvent yielded 12.2 g (42%) of pure yellow crystals of 1-phenyl-4-methylisoquinoline.

Источник