Реакция #2320127

Уравнение реакции

1-amino-2-phenylpropane

triethylamine

benzoyl chloride

→

N-(2-phenylpropyl)benzamide

Выход 95.0%

Растворители

chloroform

chloroform

Условия реакции

Обработка

1. 1
   workup.ADDITIONAfter completion of the addition
2. 2
   Температураthe reaction mixture was heated
3. 3
   Температураat reflux for 1 hour
4. 4
   ПромывкаThe solution was then washed with water
5. 5
   Сушкаthe organic layer dried over magnesium sulfate
6. 6
   ДругоеRemoval of the solvent

Методика

To a solution of 1-amino-2-phenylpropane (25.0 g, 0.185 mol) and triethylamine (18.2 g, 0.185 mol) in 150 mL of chloroform was added dropwise, a solution of benzoyl chloride (26.0 g, 0.185 mol) in 150 mL of chloroform under nitrogen. After completion of the addition, the reaction mixture was heated at reflux for 1 hour. The solution was then washed with water and the organic layer dried over magnesium sulfate. Removal of the solvent yielded 42.0 g (95%) of N-(2-phenylpropyl)benzamide as a white powder.

Источник