Реакция #2320102

ord-d42e5355e60144f5820fad73d7b915d3

Уравнение реакции

FC(F)(F)c1cc(Br)ccc1Cl
5-bromo-2-chlorobenzotrifluoride
CCCN1[C@H](C)CNC[C@@H]1C
cis-2,6-dimethyl-1-propyl-piperazine
Cl
HCl
→
CCCN1[C@H](C)CN(c2ccc(Cl)c(C(F)(F)F)c2)C[C@@H]1C
cis-4-(4-Chloro-3-trifluoromethyl-phenyl)-2,6-dimethyl-1-propyl-piperazine

Реактанты

—
( 55 )
—
( 82 )
FC(F)(F)c1cc(Br)ccc1Cl
5-bromo-2-chlorobenzotrifluoride
CCCN1[C@H](C)CNC[C@@H]1C
cis-2,6-dimethyl-1-propyl-piperazine
—
( 67 )
Cl
HCl

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    Другоеthe title compound was recovered by the procedure
  2. 2
    Другоеdescribed in Preparation 9

Методика

Beginning with 5-bromo-2-chlorobenzotrifluoride and cis-2,6-dimethyl-1-propyl-piperazine, the title compound was recovered by the procedure described in Preparation 9: m.p. 256° C. (HCl), MS m/z (rel. intensity, 70 eV)) 335 (M+, 5), 305 (55), 112 (bp), 70 (67), 56 (82).

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: USRE041315E1uspto-grants-2010_05