Реакция #2307967

ord-84004a01edaa4803a8018f5eaee77331

Уравнение реакции

CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5
Buprenorphine
CCCCCCCCCCCCCCCCCC(=O)O
stearic acid
→
CCCCCCCCCCCCCCCCCC(=O)O.CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5
Buprenorphine Stearic Acid

Реактанты

CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5
Buprenorphine
CCCCCCCCCCCCCCCCCC(=O)O
stearic acid

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    Фильтрацияsieved through a 120-mesh screen
  2. 2
    Другоеto obtain particles

Методика

Equal amounts of Buprenorphine particles (prepared as described in Example 4) above) and stearic acid (prepared as described in Example 3) were blended and ground. The ground material was compressed in a 13-mm round die, with a force of 5,000 pounds for 5 minutes. Compressed tablets were ground and sieved through a 120-mesh screen followed by a 230-mesh screen to obtain particles having a size range between 63-125 microns.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07368126B2uspto-grants-2008_05