Реакция #2307966

Уравнение реакции

Bupivacaine hydrochloride

sodium hydroxide

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Bupivacaine

Растворители

water

Условия реакции

Обработка

1. 1
   Другоеto precipitate the Bupivacaine base
2. 2
   ФильтрацияThe precipitated product was filtered
3. 3
   Промывкаfurther washed with DI water at least three times
4. 4
   ДругоеThe precipitated product was dried at ca. 40° C. in vacuum for 24 hours

Методика

Bupivacaine hydrochloride (Sigma-Aldrich Corporation, St. Louis, Mo.) was dissolved in deionized (DI) water at a concentration of 40 mg/ml (saturation). A calculated amount of sodium hydroxide (in the form of 1 N solution) was added to the solution and the pH of the final mixture was adjusted to 10 to precipitate the Bupivacaine base. The precipitated product was filtered, and further washed with DI water at least three times. The precipitated product was dried at ca. 40° C. in vacuum for 24 hours.

Источник