Реакция #2303

Уравнение реакции

4-(piperazin-1-yl)anisole

4-chloropyridine hydrochloride

ammonia

→

4-[4-(4-pyridyl)-piperazin-1-yl]anisole

Выход 31.0%

Растворители

water

Условия реакции

Обработка

1. 1
   Температураheated at 160°-170° C. (bath temperature) for 7 minutes
2. 2
   ДругоеThe solid obtained
3. 3
   Температураon cooling
4. 4
   ЭкстракцияThe solid precipitate was extracted into ethyl acetate
5. 5
   Экстракцияthe organic extract
6. 6
   Промывкаwashed with water
7. 7
   Фильтрацияfiltered through phase
8. 8
   Другоеseparating paper (Whatman 1PS)
9. 9
   Другоеevaporated
10. 10
    ДругоеThe residue was recrystallised from ethanol

Методика

4-(piperazin-1-yl)anisole (4.24 g) and 4-chloropyridine hydrochloride (3.35 g) were intimately mixed and heated at 160°-170° C. (bath temperature) for 7 minutes. The solid obtained on cooling was dissolved in water (75 ml) and the solution basified with aqueous ammonia. The solid precipitate was extracted into ethyl acetate and the organic extract washed with water, filtered through phase separating paper (Whatman 1PS) and evaporated. The residue was recrystallised from ethanol to give 4-[4-(4-pyridyl)-piperazin-1-yl]anisole (1.84 g) as a solid: m.p. 165°-167° C.; NMR (CDCl3) δ8.3(2H,d); 6.86(4H,m); 6.71(2H,d); 3.78(3H,s); 3.46(4H,m); 3.2(4H,m).

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