Реакция #2282184

Уравнение реакции

methyl laurate

sorbitan

methyl laurate

sodium methoxide methanol

sodium hypophosphite

→

sorbitan monolaurate

Условия реакции

Обработка

1. 1
   Другоеfitted with a stirring apparatus
2. 2
   Другоеwas performed at 110° C. under a nitrogen
3. 3
   Другоеfor 1 hour
4. 4
   Температураwas heated under a nitrogen stream at normal pressure to 150° C. as a reaction temperature
5. 5
   Другоеreached 150° C.
6. 6
   workup.WAITThe reaction time was 8 hours
7. 7
   Фильтрацияthe product was filtrated at 80° C.

Методика

After 469 g of a 70% by weight sorbitan aqueous solution (aldehyde value of sorbitan: 6.5 ppm) and 556 g of methyl laurate were charged into a 2000 mL four-neck flask fitted with a stirring apparatus, a thermometer, and a nitrogen gas inlet, dehydration was performed at 110° C. under a nitrogen stream at normal pressure for 1 hour and further at 110° C. under a nitrogen stream at 4 kPa for 1 hour. The whole was cooled to 65° C. and, after 35.4 g of a 5% by weight sodium methoxide methanol solution and 0.44 g of sodium hypophosphite were added thereto, was heated under a nitrogen stream at normal pressure to 150° C. as a reaction temperature. After the temperature reached 150° C., the reaction was carried out under a nitrogen stream at normal pressure. At the time point when the spot of methyl laurate as a raw material disappeared on thin-layer chromatography, it was judged that the reaction was completed. The reaction time was 8 hours and, after the completion of the reaction was confirmed, the product was filtrated at 80° C. to obtain sorbitan monolaurate.

Источник