Реакция #2275760

ord-99517f5fe8474e20a3da5170e53b166e

Уравнение реакции

O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1
N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide
O=C1CCC(n2ncc3ccccc32)CC1
4-indazol-1-yl-cyclohexanone
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(n3ncc4ccccc43)CC2)C1
title compounds
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(n3ncc4ccccc43)CC2)C1
N-{[1-(4-Indazol-1-yl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

The title compounds were prepared as white solids from the reductive amination of 4-indazol-1-yl-cyclohexanone (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in Example 2 Step C) using the procedure described in Step D of Example 1.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08324186B2uspto-grants-2012_12