Реакция #2275747

ord-0511013f0fce4bf79a569791478c1612

Уравнение реакции

O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1
N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide
Cc1ccnc(OC2CCC(=O)CC2)c1
4-(4-methyl-pyridin-2-yloxy)-cyclohexanone
Cc1ccnc(OC2CCC(N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)c1
title compounds
Cc1ccnc(OC2CCC(N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)c1
N-({1-[4-(4-Methyl-pyridin-2-yloxy)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

The title compounds were prepared as white solids from the reductive amination of 4-(4-methyl-pyridin-2-yloxy)-cyclohexanone (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in Example 2 Step C) using the procedure described in Step D of Example 1.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08324186B2uspto-grants-2012_12