Реакция #2275742

ord-aaf613bee3bc45cebfc71f87a89c7ccc

Уравнение реакции

O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1
N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide
COc1cccnc1OC1CCC(=O)CC1
4-(3-methoxy-pyridin-2-yloxy)-cyclohexanone
COc1cccnc1OC1CCC(N2CC(NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)CC1
title compounds
COc1cccnc1OC1CCC(N2CC(NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)CC1
N-({1-[4-(3-Methoxy-pyridin-2-yloxy)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

The title compounds were prepared as white solids from the reductive amination of 4-(3-methoxy-pyridin-2-yloxy)-cyclohexanone (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in Example 2 Step C) using the procedure described in Step D of Example 1.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08324186B2uspto-grants-2012_12