Реакция #2275736

ord-3cab489fb5af4ad5b6c65bc0981ee075

Уравнение реакции

O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1
N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide
O=C1CCC(n2cc(I)ccc2=O)CC1
5-iodo-1-(4-oxo-cyclohexyl)-1H-pyridin-2-one
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(n3cc(I)ccc3=O)CC2)C1
title compounds
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(n3cc(I)ccc3=O)CC2)C1
N-({1-[4-(5-Iodo-2-oxo-2H-pyridin-1-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

The title compounds were prepared as white solids from the reductive amination of 5-iodo-1-(4-oxo-cyclohexyl)-1H-pyridin-2-one (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in Example 2 Step C) using the procedure described in Step D of Example 1.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08324186B2uspto-grants-2012_12