Реакция #2275727

Уравнение реакции

1-(1,4-dioxa-spiro[4.5]dec-8-yl)-1H-pyridin-2-one

HCl

sodium bicarbonate

→

title compound

1-(4-Oxo-cyclohexyl)-1H-pyridin-2-one

Растворители

acetone

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was removed in vacuo and residue
2. 2
   Другоеpartitioned between ethyl acetate and water
3. 3
   ПромывкаThe organic layer was washed with brine
4. 4
   Сушкаdried over anhydrous Na2SO4
5. 5
   Фильтрацияfiltered
6. 6
   Концентрированиеconcentrated

Методика

A solution of 1-(1,4-dioxa-spiro[4.5]dec-8-yl)-1H-pyridin-2-one (as prepared in the previous step, ˜300 mg, 1.28 mmol)) in acetone (10 mL) was treated with 1N HCl (2 mL) at room temperature for 4 hours. The reaction was worked up with saturated sodium bicarbonate to adjust the pH to neutral. The solvent was removed in vacuo and residue partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over anhydrous Na2SO4, filtered, concentrated to afford the title compound as white solid.

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