Реакция #2271673

Уравнение реакции

6-fluoro-3-(4-piperidinyl)-1,2 benzisoxazole

K2CO3

1-[3-(3-chloropropoxy)-4-methoxy-phenyl]phenylmethanone

→

1-[3-[3-[4-(6- fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-4-methoxyphenyl]phenylmethanone

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Температураat reflux for 4 hours
2. 2
   ДругоеAt the end of the reaction
3. 3
   Другоеthe solvent was evaporated
4. 4
   Другоеthe residue was partitioned between water (150 ml) and dichloromethane (400 ml)
5. 5
   ПромывкаThe dichloromethane solution was washed with water and brine (100 ml)
6. 6
   Сушкаdried over MgSO4
7. 7
   Концентрированиеconcentrated to an oil
8. 8
   ДругоеThe purification
9. 9
   Промывкаwas done by flash chromatography over a silica gel column (SiO2: 40 g; eluted with dichloromethane, 300 ml: 1% methanol in dichloromethane, 850 ml)
10. 10
    ДругоеThe material thus obtained as a colorless oil
11. 11
    ДругоеRecrystallization from ethanol (150 ml)

Методика

A stirred mixture of 6-fluoro-3-(4-piperidinyl)-1,2 benzisoxazole (2.01 g: 9.13 mmol). K2CO3 (2.0 g) and 1-[3-(3-chloropropoxy)-4-methoxy-phenyl]phenylmethanone (3.93 g; 11.3 mmol) and acetonitrile (50 ml) was heated at reflux for 4 hours. At the end of the reaction, the solvent was evaporated and the residue was partitioned between water (150 ml) and dichloromethane (400 ml). The dichloromethane solution was washed with water and brine (100 ml), dried over MgSO4, then concentrated to an oil. The purification was done by flash chromatography over a silica gel column (SiO2: 40 g; eluted with dichloromethane, 300 ml: 1% methanol in dichloromethane, 850 ml). The material thus obtained as a colorless oil solidified on standing. Recrystallization from ethanol (150 ml) gave 1-[3-[3-[4-(6- fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-4-methoxyphenyl]phenylmethanone as white crystals. 3.07 g (63%), mp=140°-141° C.

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