Реакция #2267069

Уравнение реакции

3

3-Methyl-1-(4-nitrophenyl)-6-methoxyisochroman

sodium hydroxide

HCl

→

crude product

1-Hydroxy-3-methyl-1-(4-nitrophenyl)-6-methoxyisochroman

Растворители

DMSO

DMF

Условия реакции

Обработка

1. 1
   Экстракцияextracted with ethyl acetate three times
2. 2
   ПромывкаThe combined organic phase was washed with water in order
3. 3
   Другоеto remove DMF
4. 4
   Сушкаdried over Na2SO4
5. 5
   ДругоеRemoval of the solvent

Методика

A solution of 3 (1.3 g) in 4 ml of DMSO and 24 ml of DMF was cooled to 8-12° C. and air was passed through the mixture. To the solution was added 1.2 ml of 50% aqueous sodium hydroxide in one portion and the resulting mixture was stirred for 5 hours. HCl (1 N) was added, and extracted with ethyl acetate three times. The combined organic phase was washed with water in order to remove DMF, dried over Na2SO4. Removal of the solvent afforded syrup crude product (1.6 g), which was used directly for the next step.

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