Реакция #2267067

Уравнение реакции

3-methoxyphenylacetone

NaBH4

→

desired product 2

Выход 100.0%

1-(3-Methoxyphenyl)-2-propyl alcohol

Выход 100.0%

Растворители

methanol

Условия реакции

Обработка

1. 1
   ЭкстракцияIt was extracted with CHCl3 three times
2. 2
   ПромывкаThe combined organic phase was washed with brine
3. 3
   Сушкаdried over Na2SO4
4. 4
   ДругоеRemoval of the solvent
5. 5
   Другоеafforded the crude product
6. 6
   ДругоеPurification of the crude product

Методика

To a solution of 3-methoxyphenylacetone (1, 1.0 g) in methanol (30 ml) was added NaBH4 (360 mg) in portions in the period of 20 min at 0° C. The resulting solution was stirred at such temperature for another 40 min. No more starting materials were detected from TLC. Ice water was added to the reaction slowly. It was extracted with CHCl3 three times. The combined organic phase was washed with brine, and dried over Na2SO4. Removal of the solvent afforded the crude product. Purification of the crude product by using a silica gel column gave the desired product 2 (1.01 g, 100%).

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