Реакция #2259710

ord-5218f0cf604b4900b0bcef36fedeb687

Уравнение реакции

OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
lactose
CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
magnesium stearate
O=[Si]=O
aerosil
→
C=CC(=O)[O-]
acrylate
C=C(C)C(=O)[O-]
methacrylate

Реактанты

OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
lactose
CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
magnesium stearate
O=[Si]=O
aerosil
—
cellulose acetate

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

Following the same procedure as for Example 1, a powdery mixture consisting of 0.53% (w/w) thiametoxam, 58.97% (w/w) cellulose acetate (CA 398-10, Eastman), 40% (w/w) lactose, 0.4% (w/w) aerosil and 0.1% (w/w) magnesium stearate is compacted into tablet cores (nominal weight: 39±1 mg) using convex punches. A coating solution formed of a mixture of acrylate and methacrylate copolymers (commercially available as Eudragit RS 30 D and Eudragit RL 30 D, Röhm GmbH, Germany) is sprayed on the cores.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US09055722B2uspto-grants-2015_06