Реакция #2254199

ord-209d9e9339364d4db7de1f3c96ee0a96

Уравнение реакции

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
Apomorphine hydrochloride
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine hydrochloride
→
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3
Apomorphine

Реактанты

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
Apomorphine hydrochloride
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine hydrochloride

Реагенты

Нет

Растворители

O
water

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    workup.ADDITIONmixed thoroughly (i.e.
  2. 2
    workup.STIRRINGthe mixture was again homogenized
  3. 3
    workup.ADDITIONby addition of a suitable acid
  4. 4
    workup.ADDITIONThe solution is then poured onto a sheet
  5. 5
    Другоеdried in a heated oven

Методика

Gelatin and mannitol are dispersed in purified water and mixed thoroughly (i.e., using a vacuum mixer) and homogenized. Apomorphine hydrochloride is added and the mixture was again homogenized to ensure complete dissolution of the apomorphine hydrochloride. The pH of the solution is adjusted to about 3.0 (i.e., by addition of a suitable acid, such as citric acid). The solution is then poured onto a sheet and dried in a heated oven.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US09044475B2uspto-grants-2015_06