Реакция #220198

Уравнение реакции

Phenyl glyoxal

cyanoacetohydrazide

→

3-Oxo-5-phenyl-2,3-dihydro-pyridazine-4-carbonitrile

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling
2. 2
   Другоеthe solvent was evaporated
3. 3
   Другоеthe crude brown mixture was purified by silica chromatography (1:9 methanol/dichloromethane)
4. 4
   ДругоеThe still impure product was further recrystallized from methanol affording 70 mg pure product

Методика

Phenyl glyoxal (1.0 g, 7.46 mmol) and cyanoacetohydrazide (740 mg, 7.46 mmol) were heated to reflux in 10 mL ethanol for 16 hours. After cooling, the solvent was evaporated and the crude brown mixture was purified by silica chromatography (1:9 methanol/dichloromethane). The still impure product was further recrystallized from methanol affording 70 mg pure product.

Источник