Реакция #2201

Уравнение реакции

3-(4-chlorobenzoyl)propionic acid

hydrazine monohydrate

→

6-(4-chlorophenyl)-4,5-dihydropyridazinone

Выход 81.5%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ДругоеA thick solid was formed which
2. 2
   workup.DISSOLUTIONdissolved
3. 3
   Температураafter heating
4. 4
   ТемператураThe resulting solution was refluxed for 3 h
5. 5
   Температураcooled
6. 6
   Другоеthe solid formed
7. 7
   Фильтрацияfiltered
8. 8
   Другоеdried

Методика

To a solution of 3-(4-chlorobenzoyl)propionic acid (20 g) in absolute ethanol (200 ml) was added 5 g of hydrazine monohydrate. A thick solid was formed which dissolved after heating. The resulting solution was refluxed for 3 h, cooled and the solid formed filtered and dried to yield 16 g (80%) of 6-(4-chlorophenyl)-4,5-dihydropyridazinone.

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