Реакция #2195497

Уравнение реакции

diethyl 3-oxopentanedioate

sodium bicarbonate

Lawesson's reagent

→

title compound

Diethyl 3-thioxopentanedioate

Растворители

toluene

Условия реакции

Обработка

1. 1
   Температураthen heat
2. 2
   Температураunder reflux for 5 h
3. 3
   ТемператураCool
4. 4
   Фильтрацияfilter
5. 5
   Концентрированиеconcentrate in vacuo
6. 6
   ДругоеPurify the residue by silica gel chromatography

Методика

Dissolve 14.1 mmol of diethyl 3-oxopentanedioate in 15 mL of toluene under argon add 49.4 mmol of sodium bicarbonate and 15.1 mmol of Lawesson's reagent. Stir for 1 h at room temperature then heat under reflux for 5 h. Cool, filter, and concentrate in vacuo. Purify the residue by silica gel chromatography using ethyl acetate/hexanes eluant to yield the title compound.

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