Реакция #2195490

Уравнение реакции

2-Thiophenecarbonylchloride

tert-butyl-1-piperazinecarboxylate

→

solids

Выход 88.1%

4-(Thiophene-2-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester

Выход 88.1%

Растворители

pyridine

Условия реакции

Обработка

1. 1
   Фильтрацияthe precipitate was filtered
2. 2
   Промывкаwashed several times with water
3. 3
   Другоеdried

Методика

2-Thiophenecarbonylchloride (2.04 g, 1.49 mL) was added to a solution of tert-butyl-1-piperazinecarboxylate (2.5 g, 13.4 mmol) and DMAP (20 mg) in pyridine (15 mL) at 0° C. under N2 atmosphere and stirred at room temperature for overnight. The mixture was poured into ice water, the precipitate was filtered, washed several times with water, and dried to yield white solids (3.5 g, 88%). Mp 76° C. 1H NMR (DMSO-d6): δ 1.42 (s, 12H), 3.40 (m, 4H), 3.61 (m, 4H), 7.12 (m, 1H), 7.43 (d, J=4.1 Hz, 1H), 7.77 (d, J=4.8 Hz, 1H). EIMS m/z 297 (M+1), 319 (M+23). Anal. (C14H20N2O3S) C, H, N.

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