Реакция #2195473

ord-043dc0a2b807409b8a6633c7a76e8f91

Уравнение реакции

Oc1ccccc1
phenol
[H-].[Na+]
sodium hydride
Cl
HCl
→
c1ccc2c(c1)oc1ccccc12
Dibenzofuran

Реактанты

Oc1ccccc1
phenol
[H-].[Na+]
sodium hydride
Cl
HCl

Реагенты

Нет

Растворители

CS(C)=O
DMSO

Условия реакции

Температура
120°CELSIUS
Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    ЭкстракцияThe aqueous phase is extracted with MTB ether
  2. 2
    СушкаThe organic phase is dried over sodium sulfate
  3. 3
    Другоеevaporated
  4. 4
    Другоеchromatographed on silica gel

Методика

The phenol 10 is dissolved in DMSO under nitrogen, a 60% sodium hydride/mineral oil suspension is added, and the mixture is warmed to 120° C. After 5 hours at this temperature, the cooled batch is added to dil. HCl solution. The aqueous phase is extracted with MTB ether. The organic phase is dried over sodium sulfate, evaporated and chromatographed on silica gel.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07514127B2uspto-grants-2009_04