Реакция #2195

Уравнение реакции

4-bromomethyl-4'-chlorobenzophenone

methylmercaptan sodium

→

desired product

Выход 83.0%

4-Chloro-4'-methylthiomethylbenzophenone

Выход 83.0%

Растворители

methanol

Условия реакции

Обработка

1. 1
   Температураunder reflux
2. 2
   КонцентрированиеThe reaction mixture was concentrated
3. 3
   Экстракцияextracted with ethyl acetate
4. 4
   ПромывкаThe ethyl acetate layer was washed with water
5. 5
   Сушкаdried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONEthyl acetate was distilled off under reduced pressure
7. 7
   ПромывкаThe residual solid was washed with n-hexane

Методика

4-bromomethyl-4'-chlorobenzophenone (3.1 g) and 15% methylmercaptan-sodium aqueous solution (5.6 g) were added to methanol (150 ml), and the mixture was stirred for 30 minutes under reflux. The reaction mixture was concentrated and extracted with ethyl acetate. The ethyl acetate layer was washed with water and then dried over anhydrous magnesium sulfate. Ethyl acetate was distilled off under reduced pressure. The residual solid was washed with n-hexane to obtain the desired product (2.3 g, melting point: 59° to 61° C., yield: 83%).

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