Реакция #2192210

Уравнение реакции

3′-chloro-4′-fluoroacetophenone

triethylsilane

→

Intermediate 221.1

Выход 28.3%

2-chloro-4-ethyl-1-fluorobenzene

Выход 28.3%

Растворители

TFA

Условия реакции

Обработка

1. 1
   Концентрированиеconcentrated
2. 2
   ДругоеThe crude product was purified by flash chromatography (100% hexanes, 2×)

Методика

To a solution of 3′-chloro-4′-fluoroacetophenone (5.2 g, 30.1 mmol) in 30 mL TFA, was added triethylsilane (14.4 mL, 90.4 mmol). The mixture was stirred at rt for 15 h, then concentrated. The crude product was purified by flash chromatography (100% hexanes, 2×) to afford 1.35 g of Intermediate 221.1 as a colorless oil.

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